What is Alendronate?

Alendronate is in a class of medications used to strengthen the bone. A young bone is in a constant state of remodeling and is composed by cells called osteoblasts, whereby old bone is removed by cells called osteoclasts. Alendronate inhibits bone removal by the osteoclasts.

This medication is primarily used to treat osteoporosis (thinning of bone) in women after menopause. After menopause, there is an increased rate of bone loss (resorption). In these patients, alendronate has been shown to increase bone density while strengthening it at the same time, and decrease the rate of bone fractures.

Alendronate is also helpful in the treatment of Paget's disease of the bone. Paget's disease is characterized by a disorderly and accelerated remodeling of the bone, leading to bone weakness and pain.

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